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Prophylactic doses of mefoquine in the second and third trimesters of pregnancy also appear to be effective and are not associated with adverse maternal or fetal outcomes (49 cheap levitra soft 20mg overnight delivery low libido erectile dysfunction treatment, 50) levitra soft 20mg low cost doctor for erectile dysfunction in dubai. Dose optimization For the treatment of uncomplicated malaria in combination with artesunate, the recommended total dose of mefoquine is 25 mg/kg bw, which gives a higher cure rate than the previously recommended dose of 15 mg/kg bw. A pharmacokinetics model predicted that initial use of the lower (15-mg/kg bw) dose of mefoquine resulted in a greater likelihood of selecting resistant mutants than de novo use of the higher (25-mg/kg bw) dose (51). Giving mefoquine in two or three doses improves its tolerability and oral bioavailability. The fxed-dose combination of artesunate + mefoquine given daily for 3 days is preferred. Mefoquine A derivatives: synthesis, mechanisms of action, antimicrobial activities. Science against microbial pathogens: communicating current research and technological advances. Antimalarial quinolines and artemisinin inhibit endocytosis in Plasmodium falciparum. Stereoselective pharmacokinetics of mefoquine in healthy Caucasians after multiple doses. Bourahla A, Martin C, Gimenez F, Singhasivanon V, Attanath P, Sabchearon A, et al. Population pharmacokinetic and pharmacodynamic modelling of artemisinin and mefoquine enantiomers in patients with falciparum malaria. Studies of mefoquine bioavailability and kinetics using a stable isotope technique: a comparison of Thai patients with falciparum malaria and healthy Caucasian volunteers. Mefoquine antimalarial prophylaxis in pregnancy: dose fnding and pharmacokinetic study. Infuence of hemodialysis on plasma concentration–time profles of mefoquine in two patients with end- stage renal disease: a prophylactic drug monitoring study. Enantioselective pharmacokinetics of mefoquine during long-term intake of the prophylactic dose.

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